OSHA interprets these results to mean that there is suggestive (but not absolute) evidence that MC is a human carcinogen. Other epidemiological studies have not observed a relationship between MC exposure and cancer. There are also some human epidemiological studies which show an association between occupational exposure to MC and increases in biliary (bile duct) cancer and a type of brain cancer. No carcinogenic effects of MC were found in hamsters. MC exposure produced lung and liver tumors in mice and mammary tumors in rats. The best evidence that MC causes cancer is from laboratory studies in which rats, mice and hamsters inhaled MC 6 hours per day, 5 days per week for 2 years. Splashes of the liquid into the eyes may cause irritation. If liquid MC remains on the skin, it may cause skin burns. Skin exposure to liquid MC may cause irritation. Exposure to MC may make the symptoms of angina (chest pains) worse. High vapor concentrations may also cause irritation of the eyes and respiratory tract. Continued exposure may cause increased light-headedness, staggering, unconsciousness, and even death. Inhaling the vapor may cause mental confusion, light-headedness, nausea, vomiting, and headache. It can also affect the body if it is swallowed. MC can affect the body if it is inhaled or if the liquid comes in contact with the eyes or skin.It is slightly soluble in water and completely miscible with most organic solvents.Įxposure may not exceed 25 parts MC per million parts of air (25 ppm) as an eight-hour time-weighted average (8-hour TWA PEL) or 125 parts of MC per million parts of air (125 ppm) averaged over a 15-minute period (STEL). MC is a clear colorless liquid with a chloroform-like odor. Its solvent property is sometimes increased by mixing with methanol, petroleum naphtha or tetrachloroethylene. It is used in paint removers, in propellant mixtures for aerosol containers, as a solvent for plastics, as a degreasing agent, as an extracting agent in the pharmaceutical industry and as a blowing agent in polyurethane foams. It is a good solvent for oils, fats, waxes, resins, bitumen, rubber and cellulose acetate and is a useful paint stripper and degreaser. MC is used as a solvent, especially where high volatility is required. Appearance and odor: colorless liquid with a chloroform-like odor.Vapor pressure at 20° C (68° F): 350 mm Hg.Vapor density (air=1 at boiling point): 2.9.Synonyms: MC, Dichloromethane (DCM) Methylene dichloride Methylene bichloride Methane dichloride CAS: 75-09-2 NCI-C50102.Substance: Methylene chloride (CH 2Cl 2).Substance Safety Data Sheet and Technical Guidelines for Methylene Chloride
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